Fast absorption with lower doses
Our lungs have a huge surface area of around 70-100m2 – around the same size as a tennis court. A greater surface area allows more space for drug absorption. They also have an extremely thin air-blood barrier, just 01.-0.5 micrometres thick. This means that drugs only have to cross two cell layers to reach the bloodstream, meaning that uptake is fast and efficient. As we breathe, our lungs receive the entire cardiac output every few minutes, so inhaled drugs can enter our bloodstream as quickly as an intravenous injection. Inhalation also means that drugs bypass the liver’s first-pass effect, meaning lower doses may be effective and patients experience fewer systemic side effects. And of course, when given the choice, patients prefer the comfort and convenience of inhalation over intravenous injections.
The difference between inhalers and nebulisers
So, how to get drugs into the pulmonary system? Patients can use inhalers or nebulisers – but there are crucial differences between them. Inhalers are small and quick to use, but they require training and co-ordination to use correctly. This makes them unsuitable for very vulnerable patients or when it’s not practical to train large numbers of people to use them, for example in the event of a vaccination programme. Nebulisers are often used in hospital settings, or by the most vulnerable patients, because they only require the patient to breathe as normal. All of these benefits mean that inhalation via nebuliser is extremely suited for treating chronic conditions.
Nebu~Flow: a better patient experience
However, current nebuliser technology has many limitations when it comes to patient experience: the machines can be noisy, inefficient, hard to clean and difficult to use. All of these problems contribute to patients’ burden of disease. And as any clinician will tell you, they make it harder to ensure patient compliance. Nebu~Flow unlocks the real benefits of inhaled drug delivery. Gentle, convenient, silent and portable, it transforms the patient experience, making treatment far more comfortable and convenient.
![](data:image/svg+xml,<svg display="block" role="presentation" viewBox="0 0 90 16" xmlns="http://www.w3.org/2000/svg"><g d="M 62.254 10.535 C 62.254 7.509 64.647 5.115 67.714 5.115 C 70.781 5.115 73.197 7.488 73.197 10.535 C 73.197 13.582 70.803 15.998 67.714 15.998 C 64.626 15.998 62.254 13.582 62.254 10.535 Z M 70.738 10.535 C 70.738 8.706 69.476 7.423 67.714 7.423 C 65.954 7.423 64.712 8.729 64.712 10.535 C 64.712 12.341 65.953 13.69 67.714 13.69 C 69.476 13.69 70.738 12.384 70.738 10.535 Z M 0 0.544 L 1.74 0.544 L 9.789 11.057 L 9.789 0.544 L 12.29 0.544 L 12.29 15.781 L 10.55 15.781 L 2.503 5.268 L 2.503 15.781 L 0 15.781 Z M 13.838 10.557 C 13.838 7.487 16.209 5.115 19.233 5.115 C 22.257 5.115 24.215 7.315 24.215 10.318 C 24.215 10.667 24.172 11.014 24.085 11.449 L 16.296 11.449 C 16.645 12.886 17.776 13.757 19.342 13.757 C 20.407 13.757 21.365 13.387 21.995 12.647 L 23.518 14.193 C 22.495 15.389 20.994 16 19.36 16 C 16.228 16 13.835 13.67 13.835 10.558 L 13.837 10.557 Z M 16.296 9.49 L 21.865 9.49 C 21.56 8.097 20.647 7.314 19.188 7.314 C 17.728 7.314 16.643 8.142 16.294 9.49 Z M 25.691 0.109 L 28.085 0.109 L 28.085 6.486 C 28.825 5.637 29.956 5.115 31.284 5.115 C 34.112 5.115 36.309 7.509 36.309 10.578 C 36.309 13.648 34.112 15.998 31.284 15.998 C 29.956 15.998 28.825 15.498 28.084 14.648 L 28.084 15.78 L 25.691 15.78 Z M 33.849 10.557 C 33.849 8.684 32.631 7.379 30.89 7.379 C 29.149 7.379 27.931 8.686 27.931 10.557 C 27.931 12.427 29.129 13.734 30.89 13.734 C 32.651 13.734 33.849 12.427 33.849 10.557 Z M 37.832 11.406 L 37.832 5.333 L 40.225 5.333 L 40.225 11.297 C 40.225 12.821 41.009 13.692 42.379 13.692 C 43.748 13.692 44.532 12.842 44.532 11.297 L 44.532 5.333 L 46.925 5.333 L 46.925 11.406 C 46.925 14.149 45.075 15.998 42.379 15.998 C 39.682 15.998 37.832 14.104 37.832 11.406 Z M 58.582 0.109 L 60.975 0.109 L 60.975 15.78 L 58.582 15.78 L 58.582 0.11 Z M 73.441 5.333 L 75.921 5.333 L 78.38 11.928 L 80.773 5.333 L 82.166 5.333 L 84.559 11.928 L 87.018 5.333 L 89.498 5.333 L 85.298 15.781 L 83.905 15.781 L 81.47 9.555 L 79.033 15.781 L 77.64 15.781 Z M 52.846 5.44 C 52.913 5.458 52.978 5.47 53.045 5.484 L 53.045 4.05 C 53.045 2.897 53.697 2.243 54.851 2.243 C 55.481 2.243 55.851 2.46 56.201 2.809 L 57.745 1.263 C 56.96 0.457 56.113 0 54.85 0 C 52.4 0 50.695 1.637 50.655 3.985 C 51.377 4.647 52.013 5.217 52.845 5.438 L 52.845 5.44 Z M 51.72 8.793 C 51.349 8.693 50.99 8.554 50.648 8.379 L 50.648 15.889 L 53.042 15.889 L 53.042 8.989 C 52.596 8.973 52.153 8.907 51.721 8.794 Z M 53.816 8.316 C 53.288 8.317 52.761 8.249 52.251 8.112 C 50.797 7.723 49.818 6.826 48.955 6.033 C 47.955 5.115 47.165 4.389 45.761 4.389 C 44.914 4.389 43.58 5.083 42.939 5.522 L 41.5 3.577 C 41.735 3.415 44.006 2 45.92 2 C 48.318 2 49.55 3.276 50.67 4.302 C 51.417 4.988 52.062 5.579 52.918 5.809 C 54.64 6.269 56.28 5.21 56.296 5.2 L 57.714 7.163 C 57.629 7.219 55.971 8.316 53.816 8.316 Z" fill="transparent" height="15.999999771118164px" id="rHppGYQ0B" width="89.49800189208986px"><path d="M 62.254 10.535 C 62.254 7.509 64.647 5.115 67.714 5.115 C 70.781 5.115 73.197 7.488 73.197 10.535 C 73.197 13.582 70.803 15.998 67.714 15.998 C 64.626 15.998 62.254 13.582 62.254 10.535 Z M 70.738 10.535 C 70.738 8.706 69.476 7.423 67.714 7.423 C 65.954 7.423 64.712 8.729 64.712 10.535 C 64.712 12.341 65.953 13.69 67.714 13.69 C 69.476 13.69 70.738 12.384 70.738 10.535 Z M 0 0.544 L 1.74 0.544 L 9.789 11.057 L 9.789 0.544 L 12.29 0.544 L 12.29 15.781 L 10.55 15.781 L 2.503 5.268 L 2.503 15.781 L 0 15.781 Z M 13.838 10.557 C 13.838 7.487 16.209 5.115 19.233 5.115 C 22.257 5.115 24.215 7.315 24.215 10.318 C 24.215 10.667 24.172 11.014 24.085 11.449 L 16.296 11.449 C 16.645 12.886 17.776 13.757 19.342 13.757 C 20.407 13.757 21.365 13.387 21.995 12.647 L 23.518 14.193 C 22.495 15.389 20.994 16 19.36 16 C 16.228 16 13.835 13.67 13.835 10.558 L 13.837 10.557 Z M 16.296 9.49 L 21.865 9.49 C 21.56 8.097 20.647 7.314 19.188 7.314 C 17.728 7.314 16.643 8.142 16.294 9.49 Z M 25.691 0.109 L 28.085 0.109 L 28.085 6.486 C 28.825 5.637 29.956 5.115 31.284 5.115 C 34.112 5.115 36.309 7.509 36.309 10.578 C 36.309 13.648 34.112 15.998 31.284 15.998 C 29.956 15.998 28.825 15.498 28.084 14.648 L 28.084 15.78 L 25.691 15.78 Z M 33.849 10.557 C 33.849 8.684 32.631 7.379 30.89 7.379 C 29.149 7.379 27.931 8.686 27.931 10.557 C 27.931 12.427 29.129 13.734 30.89 13.734 C 32.651 13.734 33.849 12.427 33.849 10.557 Z M 37.832 11.406 L 37.832 5.333 L 40.225 5.333 L 40.225 11.297 C 40.225 12.821 41.009 13.692 42.379 13.692 C 43.748 13.692 44.532 12.842 44.532 11.297 L 44.532 5.333 L 46.925 5.333 L 46.925 11.406 C 46.925 14.149 45.075 15.998 42.379 15.998 C 39.682 15.998 37.832 14.104 37.832 11.406 Z M 58.582 0.109 L 60.975 0.109 L 60.975 15.78 L 58.582 15.78 L 58.582 0.11 Z M 73.441 5.333 L 75.921 5.333 L 78.38 11.928 L 80.773 5.333 L 82.166 5.333 L 84.559 11.928 L 87.018 5.333 L 89.498 5.333 L 85.298 15.781 L 83.905 15.781 L 81.47 9.555 L 79.033 15.781 L 77.64 15.781 Z M 52.846 5.44 C 52.913 5.458 52.978 5.47 53.045 5.484 L 53.045 4.05 C 53.045 2.897 53.697 2.243 54.851 2.243 C 55.481 2.243 55.851 2.46 56.201 2.809 L 57.745 1.263 C 56.96 0.457 56.113 0 54.85 0 C 52.4 0 50.695 1.637 50.655 3.985 C 51.377 4.647 52.013 5.217 52.845 5.438 L 52.845 5.44 Z M 51.72 8.793 C 51.349 8.693 50.99 8.554 50.648 8.379 L 50.648 15.889 L 53.042 15.889 L 53.042 8.989 C 52.596 8.973 52.153 8.907 51.721 8.794 Z" fill="rgb(255, 255, 255)" height="15.999999771118164px" id="xHp8vPaFa" width="89.49800189208986px"/><path d="M 12.316 6.316 C 11.788 6.317 11.261 6.249 10.751 6.112 C 9.297 5.723 8.318 4.826 7.455 4.033 C 6.455 3.115 5.665 2.389 4.261 2.389 C 3.414 2.389 2.08 3.083 1.439 3.522 L 0 1.577 C 0.235 1.415 2.506 0 4.42 0 C 6.818 0 8.05 1.276 9.17 2.302 C 9.917 2.988 10.562 3.579 11.418 3.809 C 13.14 4.269 14.78 3.21 14.796 3.2 L 16.214 5.163 C 16.129 5.219 14.471 6.316 12.316 6.316 Z" fill="rgb(255, 255, 255)" height="6.316015918178664px" id="oi5UDDihQ" transform="translate(41.5 2)" width="16.213999999999942px"/></g></svg>)
